Molecular Formula | C11H19NO3 |
Molar Mass | 213.27 |
Density | 1.17 |
Melting Point | 127-129℃ |
Boling Point | 316.6±42.0 °C(Predicted) |
Solubility | DMSO (Slightly), Methanol (Slightly) |
Appearance | Solid |
Color | White to Off-White |
pKa | 14.84±0.20(Predicted) |
Storage Condition | 2-8°C |
MDL | MFCD15071431 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 4.689 ml | 23.443 ml | 46.887 ml |
5 mM | 0.938 ml | 4.689 ml | 9.377 ml |
10 mM | 0.469 ml | 2.344 ml | 4.689 ml |
5 mM | 0.094 ml | 0.469 ml | 0.938 ml |
introduction | 2,6-diazepam [3.3] heptane has aroused strong interest in the pharmaceutical industry. 2, 6-diazospirl [3.3] heptane has been reported in the 1930s and has become a hot spot in the field of organic synthesis, while 6-hydroxy-2-azospirl [3.3] heptan-2-formate tert-butyl ester is a key intermediate in the synthesis of 2, 6-diazospirl [3.3] heptane. |
application | 6-hydroxy -2-azamol [3.3] heptane -2-formate tert-butyl ester can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. |
preparation | taking epoxy bromide as the starting material, after ring opening, it reacts with ethyl cyanoacetate in a closed loop to produce substituted cyclobutane, and forms azasolo [3.3] heptane with p-toluenesulfonyl chloride. To facilitate separation and purification, the amine was protected by Boc anhydride. Finally, 6-hydroxy-2-azolo [3.3] heptan-2-formic acid tert-butyl ester is generated. Fig. 1 roadmap for synthesis of 6-hydroxy -2-azelo [3.3] heptane -2-formate tert-butyl ester |